Red Clover

A European clover (Trifolium pratense) that has globose heads of reddish-purple flowers, is commonly cultivated as a hay, forage, and cover crop, and is naturalized in the U.S. [1]

What is Red Clover?

Red clover is a wild plant belonging to the bean family. Livestock and other animals graze on red clover. It has actually also been utilized medicinally to treat several conditions consisting of cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. Healthcare professionals think that red clover “cleansed” the blood by acting as a diuretic (helping the body get rid of excess fluid) and expectorant (helping clear lungs of mucous), enhancing flow, and assisting clean the liver. Modern clinical tests have actually shown that red clover includes isoflavones, plant-based chemicals that produce estrogen-like impacts in the body. Isoflavones have revealed potential in the treatment of numerous conditions related to menopause, such as hot flashes, cardiovascular health, and osteoporosis. However, as researchers have actually become aware of the adverse effects of taking estrogen, there is also some concern about the security of isoflavones. Plus, proof that red clover helps in reducing any menopausal symptoms, like hot flashes, is combined. [2]


Red clover (Trifolium pratense) is a flowering plant that grows 15-40 cm high. It’s eaten as a vegetable and used in supplements marketed for female health. Red clover contains chemicals called phytoestrogens that are similar to the hormone estrogen. It grows in lots of locations, consisting of Europe, main Asia, and northern Africa People frequently utilize red clover for signs of menopause, weak and brittle bones, breast discomfort, male-pattern baldness, and numerous other conditions, however there is no good clinical evidence to support any of these usages. [3]


Red Clover is native to Europe and is one of the earliest species presented into the Americas, probably showing up in the 1500’s and in the Northeastern United States, in the 18th century. Colonists brought it with them as a pasture crop for their livestock and to utilize in crop rotations [4]


Red clover is a cool-season biennial or temporary perennial with a variety of leafy put up or rising stems occurring from the woody root crown, 4 to 8 inches long. Leaves and stems are pubescent. Plants have hollow, hairy stems and branches.


The alternate leaves are made up of three brochures (trifoliate), which may or may not have a “crescent” or “watermark” on the upper surface area; stipules ovate, notably veined, 3/8 to 15/16 inch long; leaf stalks long; leaflets obovate or oval, 3/4 to 2 inches long, whole or carefully toothed; flowering heads sessile.


Flowers June to October; the flower heads, each including 40 to 100 or more flowers, are borne in compact clusters or heads; flowers rose-pink to purple; flower stalks to 1-3/16 inches long; flower heads spherical, 7/8 to 1-3/8 inches in diameter; flower stems less than 1/8 inch long; flowers 1/2 to 3/4 inch long; calyx 5/16 to 1-1/32 inches long, hairy; corolla 13/32 to 13/16 inch long, rose-pink to purple.


The fruit is a legume, less than 3/16 inch long, with 1 to 2 kidney-shaped seeds that vary in color from yellow to deep violet; produces approximately 272,000 seeds per pound.


Red clover grows finest on well drained loam soil, in damp to dry meadows, open forests, and forest margins within elevations that are generally listed below 8,500 feet. [5]

Chemistry of Red clover

To record the chemical and biologic profile of a medical stage II red clover (Trifolium pratense L.) extract by determining and measuring the major and minor elements noticeable in the high-performance liquid chromatography-ultraviolet (HPLC-UV) chromatogram and evaluating each compound for estrogenic and antioxidant activity. Individual substances in the preformulated (i.e., no excipients present) extract were identified by either chemical isolation followed by structure elucidation or matching to retention time and molecular mass of chemical standards via liquid chromatography-mass spectrometry (LC-MS) analysis. Quantitation of the quantities of substances found in the preformulated extract was done utilizing HPLC-UV or LC-MS. Separated substances or standards were examined for their ability to: (1) induce alkaline phosphatase (AP) in an endometrial cancer cell line, (2) competitively bind to recombinant human estrogen receptors (ERs) alpha (alpha) and beta (beta), and (3) act as anti-oxidants by scavenging 2,2-di( 4-tert-octylphenyl) -1- picrylhydrazyl (DPPH) totally free radicals. The preformulated red clover extract had 50% reliable concentration (EC 50) of 2.0 to 2.2 microg/mL in the AP estrogenicity assay, and 50% inhibitory concentrations (IC( 50 )s) of 18.4 to 32.6 microg/mL and 1.9 to 3.4 microg/mL in the ERalpha and ERbeta binding assays, respectively. The preformulated extract was made up of 35.54% isoflavones, 1.11% flavonoids, 0.06% pterocarpans, < Nutritional Value

The nutrients abundant in Red Clover include the minerals calcium, zinc, chromium, potassium and magnesium, in addition to the vitamins A and C, and a number of B vitamins. It likewise consists of isoflavones, a plant estrogen. Isoflavones might be useful for menopausal signs, such as hot flashes and night sweats. Nevertheless, some research studies revealed little or no beneficial effects so more comprehensive clinical trials are needed. [7]


May Help In Reducing Menopause Symptoms

What is red clover great for amongst ladies dealing with symptoms of menopause? Isoflavones can have positive impacts in lowering signs associated with estrogen loss– such as hot flashes, night sweats, trouble sleeping, weight gain, bone loss, bone fractures or osteoporosis, cardiovascular problems, and swelling of the joints. Study results analyzing the impacts of red clover in dealing with menopause signs have been somewhat mixed, however numerous have shown improvements in symptoms within months, without lots of undesirable negative effects.

An unanticipated outcome of the Women’s Health Initiative study was that scientists realized most standard hormone therapy treatments (HT) given to menopausal women included unwanted negative effects and problems, so as a result there’s been a boost in interest in option, natural alternatives for supplying menopause relief. One of the most popular uses of RC is treating hot flashes. A 2016 meta-analysis concluded that “red clover usage might decrease frequency of hot flashes, specifically in women with extreme hot flashes” A random, double-blind research study examined the impacts of phytoestrogens, including red clover isoflavones (80 milligrams a day), on menopausal women compared to a placebo for 90 days. After the initial groups finished its treatment, the women were switched to receive the opposite treatment for an additional 90 days to compare results. The outcomes revealed that red clover supplementation substantially reduced the rate of lots of menopause symptoms such as hot flashes and night sweats, and had a positive effect on vaginal cytology, suggest overall cholesterol, low-density lipoprotein-cholesterol and triglyceride levels. Cholesterol and triglycerides were only somewhat lower compared to placebo, however signs were decreased enough to impact the females’s quality of life.

On average, adult women utilizing red clover extract experience significant enhancements in the health of their scalps, hair and skin within 90 days of use, including decreasing signs of aging, collagen loss and hair thinning. Another study published in Obstetrics and Gynecology International discovered that Trifolium pratens could help in reducing symptoms like low libido, state of mind, sleep and tiredness.

Can Assist Maintain Bone Strength

Research study shows that the most common kind of osteoporosis is the type connected with ovarian hormonal agent deficiency during menopause. Therefore, RC makes a great addition to any osteoporosis diet plan. A woman’s risk for establishing osteoporosis goes up throughout menopause since estrogen is important for bone mineralization. Pre-menopausal ladies with low estrogen levels or low bone density might also gain from RC supplements. Studies using rats discovered that supplementation with isoflavones help significantly enhance bone mineral content, bone turnover, mechanical strength of the tibia, femoral weight, femoral density, and prevents the rise of serum alkaline phosphatase levels that can add to bone weakness.

Efficient in Assisting to Enhance Cardiovascular Health

Abnormally low estrogen levels not only increase the likelihood of establishing osteoporosis, but likewise raise cardiovascular risk, particularly among postmenopausal women. Research studies have actually shown that red clover advantages arterial health, minimizes the threat for atherosclerosis (solidifying or thickening of the arteries), increase blood circulation, can help manage high cholesterol and might even help avoid coronary heart disease. While a lot of research studies examining RC’s impacts on heart health have actually been performed using animals and not people, research study recommends that RC might help secure against heart problem thanks to its isoflavones, which can increase HDL “good” cholesterol, keep embolism from forming, and produce more flexibility in arteries.

May Lower the Danger for Certain Cancers

2 of the oldest uses for RC in traditional systems of medicine, consisting of Chinese medicine, include assisting to prevent cancer and to “purify the blood.” Researchers have found that isoflavones in Trifolium pratens appear to assist stop cancer cells from multiplying or growing and also might be able to cause apoptosis (self-destruction of cancer cells). The kinds of cancer more than likely impacted by RC usage consist of those related to hormone changes, such as prostate, breast and endometrial cancer. On the other hand, there’s still more to find out about how RC and isoflavones are connected to natural cancer prevention. At this time, experts indicate there’s still some unknowns when it concerns understanding all of estrogen’s effects on breast cancer, so individuals with a history or high threat for breast cancer are encouraged not to use RC till more research is conducted.

Can Assist Treat Skin Inflammation

There’s some proof that isoflavones might be useful for slowing down signs of aging on the skin, as well as reducing inflammatory skin conditions like psoriasis, eczema and different rashes. Research studies over the past numerous years reveal that RC’s results on estrogen levels offer it the majority of its anti-inflammatory, UV protective, collagen-boosting and wound-healing capacities. In older adults, RC minimizes the impacts of skin aging induced by estrogen deprivation and can assist enhance collagen production. Other reports have revealed that red clover advantages for skin consist of clinically treating wounds or burns and enhancing skin elasticity, thickness and hydration– plus possibly decreasing the look of pore size and indications of aging. Is red clover helpful for hair growth? According to some research, it’s been shown to boost the health of not only skin follicles, but likewise the scalp and nails, too. While studies are limited, some findings recommend that using products consisting of RC extract to the scalp might increase hair growth in people with hair loss (alopecia), particularly postmenopausal women.

May Fight Respiratory Infections

Trifolium pratens extract and tea is used for avoidance and treatment of breathing conditions like whooping cough, colds, asthma and bronchitis. It might help to decrease pain during health problem, and has the ability to loosen up phlegm. Because it can possibly soothe bronchial spasms, enhance sleep quality, and help flush additional mucous and fluids from the respiratory system, it’s beneficial to attempt as quickly as you feel a health problem beginning.


Red clover supplements can be discovered in standardized extract type or capsules. Isoflavones in RC supplements are really potent, so much lower doses are needed than when taking in the entire herb. Scientific trials, consisting of those made with postmenopausal ladies, have utilized differing red clover does to safely produce favorable effects. While dose depends on what you’re using it for, suggestions are as follows: As much as 85 milligrams of isoflavones daily seems to be safe for a lot of adults using RC for assist with hormonal replacement. However does can vary from 40 to 160 mg of isoflavones daily. 2 pills consisting of 20– 40 milligrams dried leaves of RC, taken one to 2 times daily, is the normal starting dose (research studies have actually discovered 40 milligrams considered 12 weeks efficient for menopausal signs and skin health, and as low as 20 grams considered 12 weeks efficient for improving bone density). In tincture form (1:5, 30 percent alcohol), start by taking 60– 100 drops one to three times daily. For the skin (topical treatments for psoriasis or eczema, for instance), use a lotion containing 10 percent to 15 percent flower heads and do not apply straight to an open injury without assistance. Keep in mind when used daily, RC might take up to 3 months/12 weeks to show complete outcomes. [8]

Adverse effects

Side effects, including nausea, muscle pains, headaches, and heavy durations in some ladies have been found due to red clovers.The safety of red clover use in clients with breast or endometrial cancer has actually not yet been developed. People with protein S shortage have an increased risk of forming embolism and red clover may increase the risk of embolisms development in these people since it has a few of the impacts of estrogen. [9]
Though unusual, potential side effects consist of vaginal finding, extended menstruation, skin inflammation, queasiness, and headache. In addition, there have actually been a few case reports of uncommon however unsafe side effects of red clover. A 53-year-old woman had a subarachnoid hemorrhage– a type of stroke– after taking a supplement including 250 mg of red clover, in addition to 8 other herbs, to treat hot flashes. That said, the hemorrhage could not be directly linked to red clover.

A 52-year-old woman reported severe stomach pain and throwing up after taking 430 mg of red clover for 3 days. The medical professionals believe red clover interfered with a psoriasis medication referred to as methotrexate. After stopping the red clover, she made a full recovery.

At-risk populations

Those with hormone-sensitive conditions, such as breast cancer, ovarian cancer, or endometriosis, need to talk to their doctor prior to taking red clover due to its estrogenic activity. Still, a 3-year, double-blind research study discovered taking 40 mg of red clover everyday to be safe for women with a family history of breast cancer. Compared with the placebo group, there was not an increased danger of breast cancer, endometrial density, or hormone changes. In spite of this research study, it is essential to talk with your doctor prior to taking red clover to ensure that it’s safe and ideal for you. Furthermore, no safety data on red clover amongst children or ladies who are pregnant or breastfeeding is offered. For that reason, it must be avoid. Lastly, red clover might slow blood clot and must be prevented by those with bleeding conditions. Further, constantly be sure to inform your doctor about any medications or herbal remedies you’re taking if you’re going to have surgery.

Drug interactions

Numerous natural herbs can interfere with the efficiency of medications. In particular, red clover might connect with contraceptive pills, methotrexate, hormone replacement treatment medications, tamoxifen, blood thinners like aspirin or Plavix, among others. A current research study in 88 females taking the breast cancer medication tamoxifen discovered red clover did not result in any drug interactions or major side effects, recommending it does not interfere with anti-estrogen medications. Regardless of this, fantastic caution needs to be utilized when taking red clover and tamoxifen until there’s more scientific security information readily available. Due to the vast array of potential drug interactions with red clover and minimal data on the subject, constantly speak with a healthcare professional prior to beginning any new supplements.


Though typically recognized as safe, red clover has small estrogenic homes and need to be prevented by those who are pregnant or breastfeeding, along with individuals with bleeding disorders or who take hormonal agent replacement treatment or other medications. [10]


Pregnant Females and Kids

Provided its similarity to estrogen and absence of safety information, red clover might not be safe for ladies who are pregnant or breastfeeding, for kids, or for women who have breast cancer or other hormone-sensitive cancers.


The phytoestrogen/isoflavone concentration in red clover can possibly cause issues with reproduction and fertility. Considering that phytoestrogens are comparable in structure to estradiol, they may disrupt regular estrogen variations that affect fertility. Studies in sheep and cows revealed that red clover feeding lowered fertility. However, no human studies are readily available. Red clover need to be avoided if you are pregnant, breastfeeding, or attempting to concieve. Its security in kids is also unidentified.

Drug Interactions

The following drugs might engage with red clover:.

  • Birth control pills
  • Estrogen
  • Medications altered by the liver (CYP1A2, CYP2C1, CYP2C9, CYP3A4 substrates)
  • Drugs that slow blood clotting
  • Tamoxifen (Nolvadex)

Red clover interacts with the CYP450 gene, which produces the protein that breaks down drugs.Red clover supplements include substances that can trigger blood thinning and prevent blood clots development. It might engage with blood slimmers, like NSAIDs, and increase the risk of bleeding. The combination of red clover supplements and methotrexate (a drug that treats cancer and rheumatoid arthritis) triggered methotrexate toxicity. The patient experienced severe toxicity and chest and stomach discomfort.

Gene Interactions


Cytochrome (CYP) 450 encodes a group of enzymes that are involved in drug metabolism (breakdown of drugs into active compounds in the body). Red clover can decrease the decrease of CYP450 enzymes. The isoflavone biochanin A (from red clover) inhibits CYP19 enzyme activity and cellular production of the enzyme. CYP19 is an enzyme responsible for a step in the formation of estrogen. Red clover hinders the liver enzymes CYP1A1, CYP1B1, and CYP2C9. This might increase the blood levels of drugs that are metabolized through these paths. In rats, red clover increased the activity of two CYP enzymes, CYP2C13 and CYP3A2. CYP3A2 resembles the human CYP3A4. Activation of this enzyme speeds up drug removal, which reduces the length and intensity of the drug’s effects.

Other Genes

  • Red clover isoflavones activate PPARy, which might affect fat cell production (differentiation) and insulin sensitivity.
  • High APOC3 levels might increase fat. Red clover decreases APOC3 activity. [11]

Red Clover Tea- How To Make

The top advantages of red clover tea include its ability to lower cholesterol, mitigate the effects of menopause, secure against prostate cancer, enhance flow, relieve the nerves, boost bone density, deal with respiratory infections, clean the skin, detoxify the body and strengthen the body immune system. Due to the existence of estrogen-like compounds in this tea, there are some negative effects, particularly for individuals who have actually been detected with hormone-dependent conditions, such as breast cancer or endometriosis. According to Cancer Research study UK researchers, Dr. Ruth C Travis and Dr. Timothy J Secret, estrogen exposure is a significant factor of risk for breast cancer. Allergic reactions and other side impacts associated with blood conditions and pregnancy need to likewise be thought about.

What is Red Clover Tea?

Red clover tea is made from the flowers and leaves of the red clover plant, which is taxonomically referred to as Trifolium pratense. This herb can be discovered throughout Asia, Europe and North America, and has been extensively applauded for its medical worth by native people and natural health specialists. Much of the health advantages credited to this natural tea are because of the presence of isoflavones (estrogen-like substances) in this plant in addition to vitamins and minerals, such as vitamin C, calcium, potassium, phosphorous and magnesium.

Advantages of Red Clover Tea

Drinking red clover tea is highly advised for people who are experiencing hormone change, cold, cough, blockage, weak immunity, osteoporosis, anxiety, tension, depression, anemia, eczema, psoriasis, unpleasant menstruation, high cholesterol, menopausal symptoms and high toxicity, as well as individuals at high risk of breast and prostate cancer.

Anticancer Prospective

A number of studies have actually linked the antioxidants and isoflavones discovered in red clover tea to anti-cancer and anti-mutagenic impacts, specifically in the avoidance of prostate cancer. However, considered that isoflavones look like estrogen in their effects, these exact same compounds can make sure cancers worse, or increase the threat of establishing them, including breast cancer and ovarian cancer. This double result of these powerful chemicals suggests that this tea must be consumed with care, and just after speaking to a doctor.

Alleviates Menstruation

Menopause can be a really demanding time in a woman’s life, as the body changes too much in such a short period of time, and can experience hot flashes, headaches, anxiety, state of mind swings, insomnia and even heart palpitations. Numerous research studies have actually shown that the isoflavones discovered in red clover tea can reduce a number of these signs and alleviate the shift. By simulating the impact of estrogen in the body, these chemicals can also relieve the discomfort of specific menstrual signs such as cramps and heavy bleeding. [3]

Skin Care

The anti-inflammatory home of this tea, in addition to its variety of minerals and immune-boosting nutrients can assist get rid of conditions like eczema, psoriasis and other irritated locations of your skin, while also stimulating the development of new cells.

Hair Care

Traditional use of this herb frequently relates to loss of hair treatment, and people brew the tea, enable it to cool, and after that apply it to their scalp and hairs of hair. This can help drive nutrients into the scalp, including antioxidants that can prevent loss of hair from the follicles, and promote a healthy shine to the hair.

Improves Bone Density

One of the biggest threats as people age is the loss of bone mineral density, particularly when women go through menopause. The estrogen-like effects of the active compounds in red clover tea help to enhance bones, while the rich mix of minerals in the tea secures versus osteoporosis.

Protects Heart Health

Research has actually revealed that red clover tea actively lowers the level of LDL cholesterol in the body, which can often lead to atherosclerosis, cardiovascular disease and strokes, in addition to heart disease. This tea likewise helps in reducing strain on the heart thanks to its blood-thinning residential or commercial properties, making embolism far less most likely.

Improves Immune System

This tea has a significant amount of vitamin C, which can promote the immune system and act as an antioxidant, looking for complimentary radicals and avoiding oxidative stress in tissues and organ systems. This ascorbic acid is also integral to the production of collagen and assists to speed healing and regrowth throughout the body.

Detoxifies the Body

Red clover tea has mild diuretic properties, indicating that it promotes urination, which helps to rid the body of excess fats, salts, toxic substances and water, easing the stress and workload in the liver and kidneys. [9]

Boosts Blood circulation

The blood-thinning residential or commercial properties of this tea make it outstanding for blood circulation, while the calcium material assists to enhance iron uptake throughout digestion. Both of these factors mean more oxygenated blood will reach the body’s extremities, skin and organ systems, suggesting much better function, faster repair and quicker regrowth of healthy new cells.

How to Make Red Clover Tea?

You can quickly make this tea in the house. Due to the widespread presence of these flowering “weeds”, lots of people pick to harvest the red clover blooms in the wild and dry them in the house. If you aren’t thinking about gathering them in the wild, you can get these from numerous herbalists and natural health shops. To harvest red clover blooms yourself, pluck off the flowering heads (not all of them from a single plant or spot), and collect them in a basket. It is best to select them 1-2 weeks after the first blossom. Position them on a drying rack or in a dry, warm, dark and well-ventilated place for 1-2 weeks. You should turn the blossoms every few days and they should not be touching one another. Once they are entirely dry, you are ready to brew your tea! Anyhow, let us go through the step by step process of making red clover tea in the house. [12]


Red clover is an extensive plant that grows wild in numerous parts of the world. Studies have actually discovered that it contains particularly high levels of chemicals known as “isoflavones”. These, in turn, act like oestrogen in the body and so are believed to help in reducing the symptoms of menopause. To date, research studies recommend that red clover appears quite safe, and in suitable doses may likewise assist to stabilize cholesterol levels in the body. [13]


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